Monsters refers to the many antagonistic creatures the player will encounter throughout the game.

Most monsters (with few exceptions) will damage Isaac by either touching him or shooting him with projectiles. Less frequently, monsters will spawn additional, lesser monsters, spread creep, or attempt to affect the player's movement. Along with the more common variety of monsters, champion versions can be found lurking about. These monsters are often like their common counterparts, but have a color tint or size change and drop basic pickups on death. There are also champion versions of most bosses.

怪物列表

Monster Description
黑色苍蝇
Black Fly.png
Tiny black fly with neutral AI. Does not hurt Isaac upon touch.
攻击苍蝇
Attack Fly.png
红色苍蝇跟着以撒,造成接触伤害。
Ring Fly
Ring Fly.png
Gathers with any other Ring Flies in the room. These flies orbit around themselves, while following Isaac.
Dart Fly
Dart Fly.png
DLC.png
Flies towards Isaac and attempts to mimic his movements. Deals contact damage.
Swarm Fly
Swarm Fly.png
DLC.png
Follows Isaac in large groups and deals contact damage.
Full Fly
Hush Fly.png
Flies toward Isaac erratically, dealing touch damage. Splits into 6 directional shots upon death.
Moter
Moter.png
Follows Isaac, similar to Attack Flies. Splits into 2 Attack Flies upon death.
Eternal Fly
Eternal Fly.png
Invulnerable fly that circles Corny Poop and various monsters. Turns into a vulnerable Attack Fly after the object or monster it circles is destroyed.
Pooter
Pooter.png
Slow-moving fly that occasionally fires single blood shots at Isaac. Does not deal touch damage.
Fat Fly
Fat Fly.png
An alternate version of the Pooter that fires 2 shots in a V-formation and does not deal touch damage.
Boom Fly
Boom Fly.png
Flies around the room diagonally, dealing touch damage and exploding upon death.
Red Boom Fly
Red Boom Fly.png
Flies around the room diagonally, dealing touch damage and exploding into 6 blood shots upon death.
Drowned Boom Fly
Drowned Boom Fly.png
DLC.png
Flies around the room diagonally, dealing touch damage. Upon death, explodes, fires four blood shots in the cardinal directions, and spawns a Drowned Charger.
Level 2 Fly
Level 2 Fly.png
Flies toward Isaac erratically, dealing touch damage.
Full Fly
Full Fly.png
Flies toward Isaac erratically, dealing touch damage. Splits into 6 directional shots upon death.
Sucker
Sucker.png
Flies slowly towards Isaac, exploding into 4 shots in the cardinal directions upon death.
Spit
Spit.png
Flies slowly towards Isaac, firing an Ipecac shot upon death.
Dip
Dip.png
Slowly dashes in random directions, dealing contact damage.
Corn Dip
Corn Dip.png
DLC.png
Quickly dashes in random directions, dealing contact damage.
Squirt
Squirt.png
Dashes towards the player and deals contact damage. Spawns 2 Dips upon death.
Dank Squirt
Dank Squirt.png
DLC.png
Dashes towards the player and deals contact damage. Spawns 2 Clots upon death.
Dinga
Dinga.png
Spawns Dips and shoots brown shots in 8 directions. Spawns 2 Squirts on death.
Spider
Spider.png
Erratically moves towards Isaac and deals touch damage.
Big Spider
Big Spider.png
Erratically moves towards Isaac and deals touch damage. Splits into two Spiders upon death.
Trite
Trite.png
Quickly leaps towards Isaac and deals touch damage.
Ragling
Ragling.png
Quickly leaps towards Isaac and deals touch damage. Randomly shoots two purple shots that orbit around it.
Level 2 Spider
Level 2 Spider.png
Crawls around the room erratically, following Isaac and dealing touch damage. Can jump small distances.
Ticking Spider
Ticking Spider.png
Crawls around the room erratically, following Isaac and dealing touch damage. Can jump small distances. Explodes upon death.
Baby Long Legs
Baby Long Legs.png
Runs away from Isaac and frequently spawns Spiders.
Small Baby Long Legs
Small Baby Long Legs.png
Runs away from Isaac and occasionally spawns Sacks.
Crazy Long Legs
Crazy Long Legs.png
Chases Isaac, dealing touch damage. Occasionally stops to spit blood shots in 8 directions.
Small Crazy Long Legs
Small Crazy Long Legs.png
Chases Isaac, dealing touch damage. Occasionally stops to spit blood shots diagonally in 4 directions.
Wall Creep
Wall Creep.png
Crawls along walls to try to line up with Isaac and shoots three blood shots in a line.
Blind Creep
Blind Creep.png
Randomly crawls along walls and shoots three spread blood shots.
Rage Creep
Rage Creep.png
Crawls along walls to try to line up with Isaac and shoots a Brimstone laser.
Boil
Boil.png
Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires multiple short-ranged blood projectiles in random directions when fully swollen.
Gut
Gut.png
Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires Ipecac shots in random directions when fully swollen.
Sack
Sack.png
Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Occasionally spawns Spiders when fully swollen.
Blue Boil
Blue Boil.png
DLC.png
Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires 1-3 blood shots towards Isaac when fully swollen.
Walking Boil
Walking Boil.png
Does not shrink or regenerate. Walks around aimlessly and fires multiple short-ranged blood projectiles in random directions.
Walking Gut
Walking Gut.png
Does not shrink or regenerate. Walks around aimlessly and fires Ipecac shots in random directions.
Walking Sack
Walking Sack.png
Does not shrink or regenerate. Walks around aimlessly and occasionally spawns Spiders.
Round Worm
Round Worm.png
Pops out of the ground in random locations and spits a blood shot at Isaac if he is in sight.
Nightcrawler
Nightcrawler.png
Pops out of the ground in random locations and fires four short-range shots that spiral outwards if Isaac is in sight.
Roundy
Roundy.png
DLC.png
Pops out of the ground in random locations, creating a small rock wave. Fires an explosive Ipecac shot at Isaac if he is in sight.
Ulcer
Ulcer.png
DLC.png
Pops out of the ground in random locations and spits a blood shot at Isaac or spawns a Dart Fly if Isaac is in sight.
Mulligan
Mulligan.png
Walks around the room, avoiding Isaac. Upon death, spawns several flies, which can be Black Flies, Attack Flies, or Pooters. Can suicide to explode and launch projectiles in the four ordinal directions while still releasing flies.
Mulligoon
Mulligoon.png
Walks around the room, avoiding Isaac. Upon death, spawns a Troll Bomb and fires four shots in the ordinal directions. Can suicide to explode, spawn a Troll Bomb, and launch projectiles in eight directions.
Mulliboom
Mulliboom.png
Chases Isaac and explodes upon death or upon touching Isaac. The explosion deals a half-heart of damage instead of the regular full heart.
Hive
Hive.png
Walks around the room, avoiding Isaac while spawning Attack Flies. Spawns a large number of flies upon death, which can be Black Flies, Attack Flies, Pooters, or Fat Flies.
Nest
Nest.png
Walks around the room, avoiding Isaac while spawning Spiders. Spawns a Big Spider or a Trite upon death.
Drowned Hive
Drowned Hive.png
DLC.png
Walks around the room, avoiding Isaac while spawning Drowned Chargers. Spawns a Drowned Charger upon death.
Swarmer
Swarmer.png
Slowly floats around the room, spawning several Pooters upon taking damage. Spawns a Boom Fly upon death.
Dukie
Dukie.png
DLC.png
Flies around the room diagonally, occasionally spitting out a Dart Fly.
Hopper
Hopper.png
Slowly hops around the room, dealing touch damage. Can turn into a Flaming Hopper by jumping into fire.
Flaming Hopper
Flaming Hopper.png
Quickly hops around the room, dealing touch damage. Covers a larger distance than the regular Hopper.
Leaper
Leaper.png
Hops around the room, dealing touch damage. Occasionally jumps high into the air, dropping down onto Isaac's position while firing 4 blood shots in the cardinal directions.
Pacer
Pacer.png
Walks aimlessly around the room.
Gusher
Gusher.png
Walks aimlessly around the room, occasionally firing short-ranged blood shots.
Black Globin's Body
Black Globin's Body.png
DLC.png
Walks aimlessly around the room, occasionally spawning spiders.
Gaper
Gaper.png
Walks towards Isaac, dealing contact damage. Usually turns into a Pacer or a Gusher upon death.
Flaming Gaper
Flaming Gaper.png
DLC.png
Walks towards Isaac, dealing contact damage. Usually turns into a Pacer or a Gusher upon death.
Flaming Gaper
Flaming Gaper.png
DLC.png
Walks towards Isaac, dealing contact damage. Usually turns into a Pacer or a Gusher upon death.
Cyclopia
Cyclopia.png
DLC.png
Walks towards Isaac, dealing contact damage and leaving behind a trail of damaging red creep. Occasionally shoots a blood shot towards Isaac.
Blue Gaper
Blue Gaper.png
DLC.png
Walks towards Isaac, dealing contact damage. Has triple the health of a normal Gaper.
Greed Gaper
Greed Gaper.png
DLC.png
Walks towards Isaac, dealing contact damage.
Gurgle
Gurgle.png
Walks towards Isaac, firing Ipecac shots at him. Can turn into a Splasher upon death.
Splasher
Splasher.png
Walks aimlessly around the room, firing Ipecac shots in random directions.
Skinny
Skinny.png
Slowly walks towards Isaac, leaving short-lasting red creep behind itself.
Rotty
Rotty.png
Slowly walks towards Isaac, leaving short-lasting red creep behind itself. Spawns a Bony or two Attack Flies upon death.
Mr. Maw
Mr Maw.png
Walks towards Isaac and attacks by launching its head towards Isaac. Turns into a Maw or Pacer upon death depending on the killed body segment.
Horf
Horf.png
Stationary enemy that fires medium ranged blood shots at Isaac.
Psychic Horf
Psychic Horf.png
Stationary enemy that fires homing shots at Isaac.
Maw
Maw.png
Slowly floats towards Isaac, firing blood shots.
Red Maw
Red Maw.png
Floats towards Isaac and explodes into 4 blood shots in the cardinal directions upon death.
Psychic Horf
Psychic Horf.png
Stationary enemy that fires homing shots at Isaac.
Bony
Bony.png
Wanders around the room and throws a bone at Isaac when he is in sight.
Black Bony
Black Bony.png
DLC.png
Wanders around the room and throws three bones in a row at Isaac when he is in sight. Explodes upon death.
Death's Head
Death's Head.png
Invulnerable enemy that moves diagonally around the room, dealing contact damage. Dies when the room is cleared.
Dank Death's Head
Dank Death's Head.png
DLC.png
Moves diagonally around the room, dealing contact damage. Needs to be killed to complete the room.
Flesh Death's Head
Flesh Death's Head.png
DLC.png
Moves diagonally around the room, dealing contact damage. Explodes into 6 blood shots in all directions upon death. Can be killed, but also dies when the room is cleared.
One Tooth
One Tooth.png
Follows Isaac and periodically dashes towards Isaac when it gets close. Deals contact damage.
Fat Bat
Fat Bat.png
DLC.png
Slowly flies towards Isaac. Shoots when Isaac aligns diagonally with it and will actively try to avoid Isaac's shots.
Lil' Haunt
Lil' Haunt.png
Follows Isaac erratically and occasionally shoots blood shots toward Isaac's destination, predicting his movements.
Wizoob
Wizoob.png
Disappears, then appears near Isaac and spits a cluster of spectral tears at him.
Red Ghost
Red Ghost.png
DLC.png
Disappears, then reappears near Isaac and fires a brimstone laser.
Fatty
Fatty.png
Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away.
Flaming Fatty
Flaming Fatty.png
DLC.png
Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away. Has a chance to leave behind a damaging flame upon death.
Conjoined Fatty
Conjoined Fatty.png
DLC.png
Slowly walks towards Isaac. Occasionally spits a line of damaging green creep towards Isaac. Turns into a regular Fatty upon death.
Blue Conjoined Fatty
Blue Conjoined Fatty.png
DLC.png
Slowly walks towards Isaac and occasionally spits a homing Ipecac shot at Isaac.
Pale Fatty
Pale Fatty.png
Slowly walks towards Isaac. Occasionally farts and shoots blood shots in 6 directions. Can turn into a Blubber upon death.
Fat Sack
Fat Sack.png
Slowly walks towards Isaac. Occasionally leaps off-screen and attempts to land on Isaac, leaving a puddle of creep and shooting blood shots in 6 directions where it lands. Can turn into a Blubber upon death.
Blubber
Blubber.png
Walks around aimlessly and randomly spews blood around itself. Can turn into a Half Sack when killed.
Half Sack
Half Sack.png
Wanders around aimlessly and leaves a trail of red creep.
Globin
Globin.png
Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, which can be killed. Will regenerate after a short period of time if not killed quickly.
Gazing Globin
Gazing Globin.png
Quickly chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, which can be killed. Will regenerate after a short period of time if not killed quickly.
Dank Globin
Dank Globin.png
DLC.png
Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, spawns a spider, and leaves a puddle of slowing black creep. Will regenerate after a short period of time if not killed quickly.
Black Globin
Black Globin.png
DLC.png
Chases Isaac, dealing a full heart of contact damage and spawning spiders. Upon taking enough damage, it separates into a head and body. The head slides towards Isaac, leaving a trail of damaging red creep. The body wanders around aimlessly, occasionally spawning spiders.
Knight
Knight.png
Moves erratically around the room and charges toward Isaac when in line of sight. Can only be damaged from behind.
Selfless Knight
Selfless Knight.png
Moves erratically around the room and charges toward Isaac very quickly when in line of sight. Can only be damaged from behind.
Floating Knight
Floating Knight.png
Behaves like the Knight but can fly over all obstacles.
Bone Knight
Bone Knight.png
DLC.png
Moves erratically around the room, charges toward Isaac when in line of sight, and leaves behind a trail of damaging red creep. Can only be damaged from behind.
Mask + Heart
Mask Heart.png
The Mask is invulnerable and moves around erratically, charging at Isaac when he lines up with it. The Heart avoids Isaac and fires 4 blood shots in the cardinal directions when Isaac gets near. Killing the Heart will automatically kill the Mask.
Clotty
Clotty.png
Randomly wanders around the room, firing 4 blood shots in the cardinal directions.
Clot
Clot.png
Randomly wanders around the room, firing 4 tar shots in the ordinal directions.
I. Blob
I. Blob.png
Randomly wanders around the room, firing 8 shots in all directions.
Mega Clotty
Mega Clotty.png
DLC.png
Slowly moves around the room, occasionally hopping and firing 6 blood shots in all directions. Splits into two Clotties upon death.
Mom's Hand
Mom's Hand.png
Falls from the ceiling. If it lands on Isaac, it deals damage and teleports the player back to the spawn room of the floor. Entering a room containing Mom's Hand will warn the player with Mom's laugh.
Mom's Dead Hand
Mom's Dead Hand.png
DLC.png
Falls from the ceiling. If it lands on Isaac, it deals damage and teleports the player back to the spawn room of the floor. If it doesn't land on Isaac, it spawns several rock waves that travel outwards. Spawns several spiders upon death. Entering a room containing Mom's Dead Hand will warn the player with Mom's laugh.
Maggot
Maggot.png
Aimlessly moves around the room, dealing contact damage.
Charger
Charger.png
Slowly moves around the room, charging at Isaac when he gets in its line of sight.
Drowned Charger
Drowned Charger.png
DLC.png
Slowly moves around the room, charging at Isaac when he gets in its line of sight. Explodes into four blood shots in the ordinal directions upon death.
Spitty
Spitty.png
Slowly moves around the room, occasionally firing a single blood shot forwards.
Conjoined Spitty
Conjoined Spitty.png
Slowly moves around the room, occasionally firing blood shots from both ends of its body.
Tumor
Tumor.png
Moves around the room diagonally, occasionally firing 6 shots. Fires more often upon getting damaged.
Psy Tumor
Psy Tumor.png
Moves around the room diagonally, occasionally firing 6 homing shots. Fires more often upon getting damaged.
Camillo Jr.
Camillo Jr.png
Moves around the room diagonally, occasionally firing Technology lasers towards Isaac. Fires more often upon getting damaged.
Brain
Brain.png
Slowly crawls around the room, leaving a trail of red creep.
MemBrain
MemBrain.png
Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions. Splits into 2 Brains upon death.
Guts
Guts.png
Attaches itself to a wall or obstacle and rolls around it.
Scarred Guts
Scarred Guts.png
DLC.png
Attaches itself to a wall or obstacle and rolls around it, leaving a trail of damaging red creep.
Mama Guts
Mama Guts.png
Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions. Splits into 2 Guts upon death.
Buttlicker
Buttlicker.png
Attaches itself to other Buttlickers and erratically moves around the room, similar to Larry Jr.
Grub
Grub.png
Erratically moves around the room like Larry Jr. and charges at Isaac when he gets within its line of sight. Spawns random types of maggots upon death, one for each of its segments.
Para-Bite
Para-Bite.png
Moves towards Isaac, dealing contact damage. Can burrow underground and reappear elsewhere.
Scarred Para-Bite
Scarred Para-Bite.png
DLC.png
Moves towards Isaac, dealing contact damage and firing short-range blood shots. Can burrow underground and reappear elsewhere.
Cod Worm
Cod Worm.png
Stationary enemy that hides in a shell and spews blood if shot at. Only vulnerable when it pops its head out.
Fred
Fred.png
Hops out of the ground and burrows elsewhere, firing 4 blood shots in the ordinal directions. Occasionally fires red Ipecac shots at Isaac.
Lump
Lump.png
Fires 3 spread blood shots at Isaac when he gets in its line of sight. Will burrow underground and reappear elsewhere after firing
Leech
Leech.png
Quickly charges towards Isaac when he gets in its line of sight.
Kamikaze Leech
Kamikaze Leech.png
Quickly charges towards Isaac when he gets in its line of sight. Explodes upon death.
Holy Leech
Holy Leech.png
Quickly charges towards Isaac when he gets in its line of sight. Explodes upon death. Spawns with an Eternal Fly circling it.
Host
Host.png
Stationary enemy that is normally invulnerable. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Upon raising its head, it will fire 3 blood shots and lower its head again.
Red Host
Red Host.png
Stationary enemy that can be damaged even when its head is lowered. Fire 5 spread blood shots when it raises its head.
Walking Host
Walking Host.png
Acts like the Host, but follows Isaac and deals contact damage.
Walking Red Host
Walking Red Host.png
Acts like the Red Host, but follows Isaac and deals contact damage.
Meatball
Meatball.png
DLC.png
Slides around the room, occasionally stopping to spew a fountain of short-range blood shots in all directions or to spit a line of damaging red creep. Spawns a Host upon death.
Nerve Ending
Nerve Ending.png
Static enemy which acts as a meat shield.
Vis
Vis.png
Charges and fires a Brimstone laser when Isaac gets in its line of sight.
Double Vis
Double Vis.png
Charges and fires a Brimstone laser which fires from both sides when Isaac gets in its line of sight.
Scarred Double Vis
Scarred Double Vis.png
DLC.png
Charges and fires a Brimstone laser which fires from all four sides when Isaac gets in its line of sight.
Chubber
Chubber.png
Fires a Charger that deals one heart of damage when Isaac gets in its line of sight. The Charger is invulnerable, blocks Isaac's tears, and has limited range.
Wall Hugger
Movingspikeblock.png
Moves around the room like Guts, damaging Isaac by contact. Cannot be destroyed.
Slide
Bluespikeblock.png
Quickly slides towards Isaac when he gets in its line of sight, then moves slowly back to its original position. Cannot be destroyed.
Poky
Poky.png
Slides around the room aimlessly, damaging Isaac by contact. Disappears when the room is cleared.
Eye
Eye.png
Slowly turns towards Isaac and fires a laser at Isaac if he stands still or is too slow.
Bloodshot Eye
Bloodshot Eye.png
Slowly turns towards Isaac and fires a Brimstone beam at Isaac if he stands still or is too slow.
Dople
Dople.png
Mirrors Isaac's movements and fires blood shots at the same time as Isaac. Can be damaged by spikes.
Evil Twin
Evil Twin.png
Mirrors Isaac's movements and fires three spread blood shots at the same time as Isaac. Can fly over obstacles.
Embryo
Embryo.png
Aimlessly hops around the room, dealing contact damage.
Baby
Baby.png
Slowly floats towards Isaac and fires blood shots. Occasionally teleports and reappears elsewhere.
安琪儿
Angelic Baby.png
缓慢的朝向以撒漂浮,发射三颗散弹。偶尔会传送并出现在别处。
Imp
Imp.png
DLC.png
Slowly drifts towards Isaac, frequently firing 5 blood shots in quick succession towards Isaac. Tries to avoid Isaac's shots and occasionally teleports and reappears elsewhere.
Homunculus
Homunculus.png
Starts attached to the wall. After a while, it detaches, shooting 6 blood shots and chasing Isaac. If it dies while still attached to the wall, it leaves a puddle of creep.
Begotten
Begotten.png
Starts attached to the wall. After a while, it detaches, turning the room dark and chasing Isaac. Phases in and out of visibility.
Null
Null.png
Act like faster Frowning Gapers. When Isaac gets near, they phase in and out of visibility and pursue Isaac faster.
Swinger
Swinger.png
Slowly moves towards Isaac as its head swings around its base. Upon death, spawns a Maw or a Globin depending on which part is killed.
Keeper
Keeper.png
Hops around the room, firing 2 blood shots in a V formation at Isaac. Upon damaging Isaac, Isaac drops 2 coins on the ground but loses 3.
Hanger
Hanger.png
Floats around the room, firing 3 spread blood shots at Isaac. Upon damaging Isaac, Isaac drops 2 coins on the ground but loses 3. Spawns with an eternal fly circling around it.
Stone Grimace
Stone Grimace.png
Stationary and invulnerable monster that occasionally fires blood shots at Isaac. Stops firing when room is cleared.
Vomit Grimace
Vomit Grimace.png
Stationary and invulnerable monster that occasionally fires an Ipecac shot at Isaac. Stops firing when room is cleared.
Gaping Maw
Gaping Maw.png
Stationary and invulnerable monster that sucks Isaac towards it, along with Isaac's tears and enemy projectiles.
Turret Grimace
Turret Grimace.png
Stationary and invulnerable monster that continuously fires shots in a single direction.
Stone Eye
Stone Eye.png
Stationary and invulnerable monster that constantly rotates and fires a flickering Technology laser. Stops firing when the room is cleared.
Brimstone Grimace
Brimstone Grimace.png
Stationary and invulnerable monster that fires Brimstone beams in a specific direction.
Oob
Oob.png
When Isaac lines up with it horizontally, it charges across the room once. When Isaac is not horizontal to it, it spawns Brains.
漆黑的胃
Black Maw.png
When Isaac lines up with it horizontally, it charges in his direction and then doubles back, charging back to its original position. When Isaac is not horizontal to it, it spawns Kamikaze Leeches. Explodes when it dies.

Champions

Ed's basic example of potential color variations.

Some monsters can spawn as a Champion which deviates in coloration and size from its more common form. The champion's coloration denotes which peculiar behaviors and traits it will exhibit. Champions will generally drop a pickup (coinciding with the color of the champion) when killed on normal difficulty. However, in hard mode, fewer champions will drop pickups on death. All champions will deal contact damage, regardless of what monster they are (e.g. a common Mulligan will not deal contact damage, but champion versions will). Some champions inflict full heart damage regardless of chapter. The likelihood of champions appearing is increased by unlocking the Everything Is Terrible! achievement, by carrying the Purple Heart trinket, by picking up the Champion Belt item, or by playing in hard mode. Champions are generally regarded as more dangerous than common monsters.

The identifying scheme for champion qualities is as follows:

Champion Types

Appearance Effect Drop
Black Fades in and out of visibility, like a Null Red Chest
Solid White Invincible until other enemies are killed Eternal Heart
Transparent White Tears become spectral tears, and it can move past environmental obstacles (such as pits) that it otherwise couldn't when forced Golden Chest
Green Leaves green creep as it walks. Pill
Dark Teal Explodes when killed. Bomb
Gray Has 2/3 health, but deals double damage. Key
Orange Attacks cause you to drop coins (like Greed or a Keeper). Coin
Purple Pulls Isaac toward it, like a Gaping Maw. random Trinket
Red ×2.5 amount of HP. Heart
Dark Red Collapses into a flesh pile upon death and regenerates if not finished off (like a Globin). 1+1 Free Heart
Yellow Increased movement and shot speed. Battery
Light Blue Releases blood shots in 8 directions when killed. 1/2 heart
Dark Blue None. 3 Blue Flies
Pink Periodically shoots short-ranged blood shots, similar to Gushers. Nothing
DLC.png Pulsing Green Splits into two copies of itself upon death. 2 normal versions of itself
DLC.png Large Increased health, decreased speed. Larger and easier to hit. Deals two full hearts of damage. One makes you larger Pill
DLC.png Tiny Decreased health, increased speed. Smaller and more difficult to hit. One makes you small Pill
DLC.png Holy Has 1-2 eternal flies circling it. Spawns another fly upon death. Attack Fly
DLC.png Camouflage The enemy blends into the background and briefly becomes visible when damaged. Rune
DLC.png Pulsing Black Repels Isaac's shots when it pulses. Heart

Monster Variants

These uncommon variants may replace common enemies in a room.

Rebirth

Base Monster Possible Replacements
Mulligan.png Mulligoon.png or Mulliboom.png
Hopper.png Trite.png
Stone Grimace.png Vomit Grimace.png
Dople.png Evil Twin.png
Eye.png Bloodshot Eye.png
Leech.png Kamikaze Leech.png or Holy Leech.png
Maw.png Red Maw.png or Psychic Maw.png
Host.png Red Host.png
Vis.png Double Vis.png or Chubber.png
Boom Fly.png Red Boom Fly.png
Pooter.png Fat Fly.png
Pacer.png Gusher.png
Knight.png Selfless Knight.png
Clotty.png or Clot.png I. Blob.png
MemBrain.png Mama Guts.png
Gaper.png Frowning Gaper.png
Globin.png Gazing Globin.png
Baby.png Angelic Baby.png
Boil.png or Sack.png Gut.png
Sucker.png Spit.png

Afterbirth

Base Monster Possible Replacements
Gaper.png Flaming Gaper.png
Fatty.png Flaming Fatty.png
Hive.png Drowned Hive.png
Charger.png Drowned Charger.png
Squirt.png Dank Squirt.png
Death's Head.png Dank Death's Head.png or Flesh Death's Head.png
Globin.png Dank Globin.png
Guts.png Scarred Guts.png
Para-Bite.png Scarred Para-Bite.png
Double Vis.png Scarred Double Vis.png
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