掉落
硬币 炸弹 钥匙 电池 胶囊 卡片 宝箱 DLC.png 袋子

Pills are pickups that can provide useful or inhibiting effects. They take up the same slot as cards and runes.

At the start of each run, an effect is randomly assigned to each color of pill. The pill effect for that color will remain constant throughout the run. (However, it is possible for PHD or Virgo to reassign some of the effects.) The set of pill effects for any given run is usually known as the pill pool.

  • DLC.png The pill pool for each run has increased from 9 to 13.


Pill Effects

Pill Effect
48 Hour Energy

Drops one to two battery charges and fully charges the spacebar item. DLC.png Can be used with the Placebo to generate infinite batteries.

Amnesia

Replaces the floor map with a ? for the rest of the floor. If no other curses are active for the floor, the Curse of the Lost will appear under the level name when TAB is held. This effect cannot be negated by Black Candle. DLC.png Also the only pill to have its flavour text appear on a piece of paper, like curses do.

Bad Gas

Isaac farts, poisoning enemies around him.

Bad Trip

Injures Isaac by a full heart. If a Bad Trip pill is used while Isaac only has a single heart left or less, the pill will turn into a Full Health pill instead. (This damage counts as red heart damage for the purposes of getting a Devil Deal.)

Balls of Steel

Grants Isaac two soul hearts.

Bombs Are Key

Switches number of bombs and keys.

Explosive Diarrhea

Spawns five active bombs behind Isaac over a period of five seconds, at one a second.

Full Health

Restores all health.

Health Down

Removes one red heart container upon use. While Isaac has one or fewer red heart containers, it will act as a Health Up pill instead.

Health Up

Adds one empty red heart container upon use.

Hematemesis

Empties all but one red heart container and spawns 1-4 full red heart pickups. If Isaac only has half of a heart left, it will heal him to one heart. If used without any red heart containers, no health will be deducted, but red hearts will still spawn. If used in a Black Heart or Eternal Heart-containing Super Secret Room, it will spawn those types of hearts instead.

I Can See Forever

Opens all entrances to the Secret Room and Super Secret Room for the current floor.

I Found Pills

Changes the appearance of Isaac's face. This pill is cosmetic only, and the effect disappears when you leave the room.

Lemon Party

Spawns a large yellow pool (similar to Lemon Mishap) around your character. Greatly damages any enemy that steps on it.

Luck Down

Decreases Isaac's luck by 1.

Luck Up

Increases Isaac's luck by 1.

Paralysis

Prevents Isaac from moving for a short duration.

Pheromones

Charms all enemies in the room for a short period of time.

Puberty

Causes Isaac to grow four hairs from the top of his head and zits on his face. This pill is cosmetic only, and will stay for the rest of the run.

Pretty Fly

Grants 1 fly orbital that circles the player, blocking projectiles and damaging fly-type enemies on touch.

Range Down

Decreases Isaac's range by 2.

Range Up

Increases Isaac's range by 2.5.

R U a Wizard?

Tears are shot diagonally outwards for about one minute. This effect does not reset upon exiting the room.

Speed Down

Decreases Isaac's movement speed by 0.12.

Speed Up

Increases Isaac's movement speed by 0.15.

Tears Down

Decreases Isaac's tears by 0.28.

Tears Up

Increases Isaac's tears by 0.35.

Telepills

Isaac gets teleported to a random room. Has a small chance to teleport Isaac to the I AM ERROR room, and an extremely small chance to teleport him to the Black Market, like Undefined.

DLC.png Afterbirth
Addicted

Makes Isaac take a full heart of damage from all sources for the current room. Unlocked by completing Challenge #24: PAY TO PLAY.

Friends Till The End!

Spawns three Blue Flies.

Infested!

Destroys all poop in the room and spawns a single Blue Spider under Isaac and on each destroyed poop.

Infested?

Spawns Blue Spiders equal to the number of enemies in the room. If there are no enemies in the room, spawns 1-3 Blue Spiders.

One Makes You Small

Decreases Isaac's size and increases the pitch of his voice. This effect decreases the size of Isaac's hitbox.

One Makes You Larger

Increases Isaac's size and decreases the pitch of his voice. This effect does not increase the size of Isaac's hitbox.

Percs

Gives The Wafer effect while in the room. Unlocked by completing Challenge #24: PAY TO PLAY.

Power Pill

Activates an effect similar to The Gamekid.

Re-Lax

For a short time, poop spawns wherever Isaac moves, like Explosive Diarrhea but with poop. A higher move speed means you can touch more tiles in the same time. A pun on laxatives. Unlocked by completing Challenge #25: Have A Heart.

Retro Vision

Briefly pixelates the screen 3 times over 30 seconds.

???

Gives the Curse of the Maze effect for the remainder of the floor. The effect can stack with other curses. If no other curses are active for the floor, Curse of the Maze will appear under the level name when TAB is held. This effect cannot be negated by Black Candle. Unlocked by completing Challenge #25: Have A Heart.

Pill Appearances

BlueBlue.png RedSpecled.png YellowOrange.png Pill WhiteWhite.png WhiteBlue.png BlueCyan.png OrangeOrange.png WhiteRed.png SpottedwhiteWhite.png

DLC.png Pill Black White.png Pill Black Yellow.png Pill White Cyan.png Pill White Yellow.png

Notes

  • Among the attribute modifying pill effects, only five of the seven visible attributes are covered: health, range, tears, speed, and luck. Both shot speed and damage can't be altered by pills.
  • DLC.png Pill effects are narrated upon use, as are cards and runes.
  • Currently, the "Retro Vision" pill effect can crash the game on some machines, resulting in restarting the current floor when the game is continued.

Strategy

  • Use of unidentified pills is recommended for outside of combat as Hematemesis, R U a Wizard, Paralysis, and Addicted! can be detrimental mid-fight. However, Percs, Power Pill, Lemon Party, Bad Gas, and Pheromones are nearly useless outside of combat. The shield effects like from Power Pill can be utilized for Curse Rooms.

其他消耗品

除了卡片、符文和胶囊外,消耗品栏位中还可装备其他物品。掉落在地面上待拾取时,可以通过独特图标来辨别这些物品。

名称 图标 附注 效果
DLC.png紧急联络
Emergency Contact
45x45px"从天而降的帮助"使用后降下两只妈手,随机消灭两个敌人。
如果被抓住的是Boss,则改为不能行动。
如果房间内只有一个敌人,则只降下一只妈手。
DLC.png骰子碎片
Dice Shard
Dice Shard Icon.png"D6+D20"使用后触发一次D6+D20效果(重置当前房间的所有主被动道具和掉落)。

Trivia

  • Hematemesis is the vomiting of blood.
  • Lemon Party is an internet shock site featuring a group of elderly men performing oral sex.
  • I Found Pills (and Ate Them), R U a Wizard? and I can see Forever are all image macro memes.
  • Balls of Steel is a reference to Duke Nukem; it is one of Duke's more famous quotes.
  • In the original game, Wrath of the Lamb, there was another positive pill effect called "Friends Til The End", which summoned 3 blue attack flies. This effect was improved and given to the Rune Berkano in Rebirth. Note that the "Infested?" and "Infested!" pill effects in Afterbirth are similar to the original "Friends Til The End" effect, only with spiders instead of flies.
    • DLC.png The pill effect was re-added.
  • 48 Hour Energy is a reference to the drink 5 Hour Energy.
  • DLC.png "One makes you larger" and "One makes you small" reference the song "White Rabbit" by Jefferson Airplane, which in turn references Alice in Wonderland.
  • DLC.png "Percs" is a reference to a street name for the prescription drug Percocet, which is more generically known as Oxycodone. This drug is meant to be used to treat pain, but often abused for recreational purposes.
  • "Pretty Fly" is a reference to The Offspring's song, "Pretty Fly (For a White Guy)".

SmallIsaac.png 以撒的结合:重生 SmallIsaac.png

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